AC-11 for DNA Repair

Uforia Science is bringing AC-11 for DNA Repair mainstream.

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The development of AC-11 started when Dr. Pero of Lund University (Sweden), the leading expert on this extract, discovered a new component in cat’s claw based on his study for over 30 years. After testing various plant species, he found that the component called CAEs in cat’s claw bark was highly effective in promoting DNA repair. In order to extract CAEs effectively from cat’s claw bark, he decided to perform fractionation using a US patented proprietary method (hot water extraction). By virtue of hot water extraction, AC-11 is a safe material that has not undergone any chemical treatment and does not contain indole alkaloids. It is now widely chosen as an ingredient of supplements and cosmetics for aging care and beauty treatment.

What is AC-11?

ac-11® is an organic, water soluble rainforest plant extract from Uncaria tomentosa, a plant indigenous to the rainforest regions of Brazil and Peru. Pure, bioactive ac-11® is the only known plant extract in the world shown by research studies to enhance the cellular DNA repair process, among other cellular benefits, such as inflammation suppression and apoptosis inducement. ac-11® is the intersection of nature’s medicinal power and advanced phytonutrient science. ac-11® is classified as a phytonutrient. The term “phyto” originates from the Greek word for plant. Phytonutrients are the organic components of plants that promote health in humans and animals. The power of healing foods, vis-a-vis phytonutrients, lies within a food’s broad-based ability to prevent disease by nutritionally fortifying the biochemical processes that have been naturally selected by evolution to protect us from illness and other chronic conditions of aging.

AC-11 Scientific Studies Continue and show positive results

Reduced non-melanoma skin cancer following topical application of AC-11 in hairless mice (an unpublished study) is likely from a reduced dimer burden. Decreased dimers – decreased p53 mutations – decreased actinic ketatosis – decreased malignancies.

The DNA data in humans has been supplemented with two animal studies in which the effects of known DNA damaging agents were compared in
AC-11-treated and control animals.

In the first study of AC-11, 8 daily doses of 40 mg/kg or 80 mg/kg of AC-11 were administered to 20 rats (an additional 10 rats served as controls) by gavage for 8 weeks. Half the animals from each group were exposed to 12 Gy whole body radiation (137Cs source) and allowed 3 hours to repair in vivo before DNA damage was assessed. AC-11-treated animals almost completely repaired single-strand DNA breaks (p < 0.05) for both AC-11 doses compared to untreated animals. Double-strand DNA breaks were substantially fewer in animals treated with 40 mg/kg/day of AC-11 and significantly (p < 0.05) fewer in animals treated with 80 mg/kg/day of AC-11 compared to untreated animals

In the second study, 9 daily doses of 40 mg/kg or 80 mg/kg of AC-11 were administered orally to 8 rats (4 at each dose) 24 hours after the last of three 2 mg/kg intraperitoneal doses of doxorubicin. Four animals received doxorubicin only. Animals treated with 80 mg/kg of AC-11 had significantly (p < 0.05) reduced DNA damage in the form of single-strand DNA breaks

More recently Dr. Pero reported on the combination of a cat’s claw water extract (AC-11, carboxy alkyl esters = active ingredients) plus medicinal mushroom extracts (Cordyceps sinensis, Grifola blazei, Grifolafrondosa, Trametes versicolor and Ganoderma lucidum, polysaccharides = active ingredients) plus nicotinamide plus zinc into a formulation designed to optimize different modes of immunostimulatory action in 14 subjects treated for 4 weeks and found patient experienced reduced pain, reduced fatigue, weight loss and a reduced presence of DNA damage in peripheral blood assessed by (8-OH) guanine DNA adducts and elevation in serum protein thiols

The mechanism for AC-11 activity has yet to be fully defined; however, research in humans and in human living skin equivalents shows that
AC-11 reduces erythema and blistering after ultraviolet exposure. AC-11 significantly enhanced the repair, but not the formation, of cyclobutyl pyrimidine dimers (TT-dimers) in human living skin equivalents exposed to UV-B light

In a study of 5 healthy volunteers aged 35 to 55 year old taking 350 mg/day of AC-11 orally for 4 weeks, 8-hydroxyguanine levels were significantly
(p < 0.05) decreased. The beneficial effect was noted to persist 2 weeks after therapy was discontinued.

Another study reported a significant (p < 0.05) decrease in DNA single-strand breaks following peroxide-induced DNA damage in monocytes of healthy volunteers who received 8 weeks of AC-11 at 350 mg/day

Pero et al. assessed oxidative DNA damage in 14 volunteers, most of whom (more than 75 %) had chronic diseases, and reported that 9 of the 14 volunteers had decreased 8-hydroxyguanine DNA adducts after 400 mg of AC-11 per day for 4 weeks. Finally, in a in a single-blind, right side-left side, beach sun exposure pilot study that included 42 healthy volunteers there were dramatic and significant (p < 0.0001) reductions in erythema and blistering in volunteers who applied 0.5 percent topical AC-11 with an SPF-15 sunscreen when compared to the group who just applied an SPF-15 sunscreen

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